Open Access

The role of sphingolipid signalling in diabetes‑associated pathologies (Review)

  • Authors:
    • Mei Li Ng
    • Carol Wadham
    • Olga A. Sukocheva
  • View Affiliations

  • Published online on: January 11, 2017     https://doi.org/10.3892/ijmm.2017.2855
  • Pages: 243-252
  • Copyright: © Ng et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Sphingosine kinase (SphK) is an important signalling enzyme that catalyses the phosphorylation of sphingosine (Sph) to form sphingosine‑1‑phosphate (S1P). The multifunctional lipid, S1P binds to a family of five G protein-coupled receptors (GPCRs). As an intracellular second messenger, S1P activates key signalling cascades responsible for the maintenance of sphingolipid metabolism, and has been implicated in the progression of cancer, and the development of other inflammatory and metabolic diseases. SphK and S1P are critical molecules involved in the regulation of various cellular metabolic processes, such as cell proliferation, survival, apoptosis, adhesion and migration. There is strong evidence supporting the critical roles of SphK and S1P in the progression of diabetes mellitus, including insulin sensitivity and insulin secretion, pancreatic β‑cell apoptosis, and the development of diabetic inflammatory state. In this review, we summarise the current state of knowledge for SphK/S1P signalling effects, associated with the development of insulin resistance, pancreatic β‑cell death and the vascular complications of diabetes mellitus.
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January 2017
Volume 39 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Ng, M.L., Wadham, C., & Sukocheva, O.A. (2017). The role of sphingolipid signalling in diabetes‑associated pathologies (Review). International Journal of Molecular Medicine, 39, 243-252. https://doi.org/10.3892/ijmm.2017.2855
MLA
Ng, M. L., Wadham, C., Sukocheva, O. A."The role of sphingolipid signalling in diabetes‑associated pathologies (Review)". International Journal of Molecular Medicine 39.2 (2017): 243-252.
Chicago
Ng, M. L., Wadham, C., Sukocheva, O. A."The role of sphingolipid signalling in diabetes‑associated pathologies (Review)". International Journal of Molecular Medicine 39, no. 2 (2017): 243-252. https://doi.org/10.3892/ijmm.2017.2855