Open Access

Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)

  • Authors:
    • Jun Li
    • Lin Ye
    • Sioned Owen
    • Hoi Ping Weeks
    • Zhongtao Zhang
    • Wen G. Jiang
  • View Affiliations

  • Published online on: October 23, 2015     https://doi.org/10.3892/ijmm.2015.2390
  • Pages: 1451-1463
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The CCN family of proteins comprises the members CCN1, CCN2, CCN3, CCN4, CCN5 and CCN6. They share four evolutionarily conserved functional domains, and usually interact with various cytokines to elicit different biological functions including cell proliferation, adhesion, invasion, migration, embryonic development, angiogenesis, wound healing, fibrosis and inflammation through a variety of signalling pathways. In the past two decades, emerging functions for the CCN proteins (CCNs) have been identified in various types of cancer. Perturbed expression of CCNs has been observed in a variety of malignancies. The aberrant expression of certain CCNs is associated with disease progression and poor prognosis. Insight into the detailed mechanisms involved in CCN-mediated regulation may be useful in understanding their roles and functions in tumorigenesis and cancer metastasis. In this review, we briefly introduced the functions of CCNs, especially in cancer.

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December 2015
Volume 36 Issue 6

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APA
Li, J., Ye, L., Owen, S., Weeks, H.P., Zhang, Z., & Jiang, W.G. (2015). Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review). International Journal of Molecular Medicine, 36, 1451-1463. https://doi.org/10.3892/ijmm.2015.2390
MLA
Li, J., Ye, L., Owen, S., Weeks, H. P., Zhang, Z., Jiang, W. G."Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)". International Journal of Molecular Medicine 36.6 (2015): 1451-1463.
Chicago
Li, J., Ye, L., Owen, S., Weeks, H. P., Zhang, Z., Jiang, W. G."Emerging role of CCN family proteins in tumorigenesis and cancer metastasis (Review)". International Journal of Molecular Medicine 36, no. 6 (2015): 1451-1463. https://doi.org/10.3892/ijmm.2015.2390