Alleviation of atopic dermatitis-related symptoms by Perilla frutescens Britton

  • Authors:
    • Jin-Chul Heo
    • Dong-Yoon Nam
    • Myung Sun Seo
    • Sang-Han Lee
  • View Affiliations

  • Published online on: August 2, 2011     https://doi.org/10.3892/ijmm.2011.763
  • Pages: 733-737
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Abstract

To ascertain whether an aqueous fraction of Perilla frutescens Britton (PfB/af) has advantageous anti-atopic dermatitis activity, we used a 2,4-dinitrofluorobenzene (DNFB)-induced animal model of atopic dermatitis symptoms to investigate the effects of the extract. We performed an ear swelling assay by comparing thickness of the DNFB-induced ear, and measured the numbers of eosinophils as well as total immune cells. We analyzed the expression levels of matrix metalloproteinase (MMP)-9, interleukin (IL)-31 and of the T-bet transcription factor. The results revealed that PfB/af (100 µg/ml) exhibited strong anti-atopic dermatitis activity, interceding drastic reduction (35%) of the immune response, as measured by the thickness of ear epidermis swelling, and resulting in decreased eosinophil levels (73.7%) in adjacent skin tissues. Collectively, the present results suggest that PfB/af has potential for mitigation of atopic dermatitis-like symptoms induced by DNFB in the mouse.

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November 2011
Volume 28 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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APA
Heo, J., Nam, D., Seo, M.S., & Lee, S. (2011). Alleviation of atopic dermatitis-related symptoms by Perilla frutescens Britton. International Journal of Molecular Medicine, 28, 733-737. https://doi.org/10.3892/ijmm.2011.763
MLA
Heo, J., Nam, D., Seo, M. S., Lee, S."Alleviation of atopic dermatitis-related symptoms by Perilla frutescens Britton". International Journal of Molecular Medicine 28.5 (2011): 733-737.
Chicago
Heo, J., Nam, D., Seo, M. S., Lee, S."Alleviation of atopic dermatitis-related symptoms by Perilla frutescens Britton". International Journal of Molecular Medicine 28, no. 5 (2011): 733-737. https://doi.org/10.3892/ijmm.2011.763