Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis

  • Authors:
    • Yanmei Hou
    • Zhenli Qin
    • Kefeng Fan
    • Yanhua Xu
    • Xiaoge Huang
  • View Affiliations

  • Published online on: December 6, 2017     https://doi.org/10.3892/etm.2017.5601
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Abstract

Adenomyosis is a pathological gynaecological condition characterized by benign invasion of the endometrium into the myometrium. High intensity focused ultrasound (HIFU) is one of the most common therapeutic strategies for the treatment of adenomyosis. However, the efficacy of single HIFU therapy is insufficient for the treatment of patients with adenomyosis. In the present study, the efficacy of HIFU and metformin for the treatment of adenomyosis was analyzed in 274 patients with adenomyosis who were admitted to Jinan Maternity and Child Care Hospital. The results demonstrated that there was a significant reduction in menstrual flow and pain between patients who received HIFU and metformin, and those who received single HIFU treatment (P<0.01). Furthermore, the outcomes demonstrated that inflammatory cytokines levels were significantly lower compared with the baseline values (P<0.01). In conclusion, the outcomes of the current study indicate that combined HIFU and metformin treatment is more efficacious in patients with enlarged adenomyosis compared with single HIFU treatment.

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Print ISSN: 1792-0981
Online ISSN:1792-1015

2016 Impact Factor: 1.261
Ranked #50/128 Medicine Research and Experimental
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APA
Hou, Y., Qin, Z., Fan, K., Xu, Y., & Huang, X. (1899). Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis. Experimental and Therapeutic Medicine, 0, 0-0. https://doi.org/10.3892/etm.2017.5601
MLA
Hou, Y., Qin, Z., Fan, K., Xu, Y., Huang, X."Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis". Experimental and Therapeutic Medicine 0.0 (1899): 0-0.
Chicago
Hou, Y., Qin, Z., Fan, K., Xu, Y., Huang, X."Combination therapeutic effects of high intensity focused ultrasound and Metformin for the treatment of adenomyosis". Experimental and Therapeutic Medicine 0, no. 0 (1899): 0-0. https://doi.org/10.3892/etm.2017.5601