Intake of kale suppresses postprandial increases in plasma glucose: A randomized, double-blind, placebo-controlled, crossover study

  • Authors:
    • Sumio Kondo
    • Asahi Suzuki
    • Mihoko Kurokawa
    • Keiji Hasumi
  • View Affiliations

  • Published online on: September 29, 2016     https://doi.org/10.3892/br.2016.767
  • Pages: 553-558
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Abstract

Kale (Brassica oleracea var. acephala), a vegetable in the family Brassicaceae, has beneficial effects on health, including hypoglycemic effects. In our previous study with a limited number of subjects, intake of kale-containing food at a dose of 14 g decreased postprandial plasma glucose levels. In the present study, the effective dose of kale-containing food was investigated in a randomized, double‑blind, placebo‑controlled, crossover trial. The trial was conducted on 42 Japanese subjects aged 21‑64 years with fasting plasma glucose levels of ≤125 mg/dl and 30‑min postprandial plasma glucose levels of 140‑187 mg/dl. The subjects consumed placebo or kale‑containing food [7 or 14 g; low‑dose (active‑L) or high‑dose (active‑H) kale, respectively] together with a high‑carbohydrate meal. At 30‑120 min after the test meal intake, the plasma levels of glucose and insulin were determined. The postprandial plasma glucose levels in subjects with intake of active‑L or active‑H were significantly lower than those in subjects with intake of placebo, with the maximum plasma concentration (Cmax; 163±24 mg/dl for active‑L and 162±23 mg/dl for active‑H compared with 176±26 mg/dl for placebo [values presented as means ± standard deviation (SD); P<0.01]. The area under the plasma glucose concentration‑time curve for 0‑2 h (AUC0‑2 h) values (means ± SD) were significantly lower for active‑L (268±43 mg/h/dl) and active‑H (266±42 mg/h/dl) than for the placebo (284±43 mg/h/dl; P<0.05). No significant differences were identified in the postprandial plasma insulin levels between the three conditions. No adverse events associated with intake of either dose of kale were observed. Our findings suggest that intake of kale suppresses postprandial increases in plasma glucose levels at a single dose of 7 g, and that a dose as high as 14 g is safe.

References

1 

International Diabetes Federation (IDF), . IDF Diabetes Atlas. 7th. IDF; Brussels: 2015

2 

Tabák AG, Herder C, Rathmann W, Brunner EJ and Kivimäki M: Prediabetes: A high-risk state for diabetes development. Lancet. 379:2279–2290. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Grundy SM: Pre-diabetes, metabolic syndrome, and cardiovascular risk. J Am Coll Cardiol. 59:635–643. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Knowler WC, Fowler SE, Hamman RF, Christophi CA, Hoffman HJ, Brenneman AT, Brown-Friday JO, Goldberg R, Venditti E and Nathan DM: Diabetes Prevention Program Research Group: 10-year follow-up of diabetes incidence and weight loss in the Diabetes Prevention Program Outcomes Study. Lancet. 374:1677–1686. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Gerstein HC, Yusuf S, Bosch J, Pogue J, Sheridan P, Dinccag N, Hanefeld M, Hoogwerf B, Laakso M, Mohan V, et al: DREAM (Diabetes REduction Assessment with ramipril and rosiglitazone Medication) Trial Investigators: Effect of rosiglitazone on the frequency of diabetes in patients with impaired glucose tolerance or impaired fasting glucose: A randomised controlled trial. Lancet. 368:1096–1105. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Knowler WC, Barrett-Connor E, Fowler SE, Hamman RF, Lachin JM, Walker EA and Nathan DM: Diabetes Prevention Program Research Group: Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med. 346:393–403. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Ramachandran A, Snehalatha C, Mary S, Mukesh B, Bhaskar AD and Vijay V: Indian Diabetes Prevention Programme (IDPP): The Indian Diabetes Prevention Programme shows that lifestyle modification and metformin prevent type 2 diabetes in Asian Indian subjects with impaired glucose tolerance (IDPP-1). Diabetologia. 49:289–297. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Heianza Y, Hara S, Arase Y, Saito K, Fujiwara K, Tsuji H, Kodama S, Hsieh SD, Mori Y, Shimano H, et al: HbA1c 5·7-6·4% and impaired fasting plasma glucose for diagnosis of prediabetes and risk of progression to diabetes in Japan (TOPICS 3): A longitudinal cohort study. Lancet. 378:147–155. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Tabák AG, Jokela M, Akbaraly TN, Brunner EJ, Kivimäki M and Witte DR: Trajectories of glycaemia, insulin sensitivity, and insulin secretion before diagnosis of type 2 diabetes: An analysis from the Whitehall II study. Lancet. 373:2215–2221. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Node K and Inoue T: Postprandial hyperglycemia as an etiological factor in vascular failure. Cardiovasc Diabetol. 8:232009. View Article : Google Scholar : PubMed/NCBI

11 

Trapp C and Levin S: Preparing to prescribe plant-based diets for diabetes prevention and treatment. Diabetes Spectrum. 25:38–44. 2012. View Article : Google Scholar

12 

Orlich MJ and Fraser GE: Vegetarian diets in the Adventist Health Study 2: A review of initial published findings. Am J Clin Nutr. 100(Suppl 1): 353S–358S. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Yokoyama Y, Barnard ND, Levin SM and Watanabe M: Vegetarian diets and glycemic control in diabetes: A systematic review and meta-analysis. Cardiovasc Diagn Ther. 4:373–382. 2014.PubMed/NCBI

14 

Hobden MR, Guérin-Deremaux L, Rowland I, Gibson GR and Kennedy OB: Potential anti-obesogenic properties of non-digestible carbohydrates: Specific focus on resistant dextrin. Proc Nutr Soc. 74:258–267. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Murayama Y, Mochizuki K, Shimada M, Fujimoto S, Nukui K, Shibata K and Goda T: Dietary supplementation with alpha-amylase inhibitor wheat albumin to high-fat diet-induced insulin-resistant rats is associated with increased expression of genes related to fatty acid synthesis in adipose tissue. J Agric Food Chem. 57:9332–9338. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Korenori Y, Suzuki A, Kurokawa M and Saito J: Beneficial effects of dietary intake of food containing kale (Brassica oleracea var. acephala) on postprandial blood glucose in humans. A randomized, placebo-controlled, double-blind, crossover study. Jpn Pharmacol Ther. 43:1157–1163. 2015.

17 

Kim SY: Comparison of nutritional compositions and antioxidant activities of building blocks in shinseoncho and kale green vegetable juices. Prev Nutr Food Sci. 17:269–273. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Sikora E and Bodziarczyk I: Composition and antioxidant activity of kale (Brassica oleracea L. var. acephala) raw and cooked. Acta Sci Pol Technol Aliment. 11:239–248. 2012.PubMed/NCBI

19 

Ismail A, Marjan ZM and Foong CW: Total antioxidant activity and phenolic content in selected vegetables. Food Chem. 87:581–586. 2004. View Article : Google Scholar

20 

Migliozzi M, Thavarajah D, Thavarajah P and Smith P: Lentil and kale: Complementary nutrient-rich whole food sources to combat micronutrient and calorie malnutrition. Nutrients. 7:9285–9298. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Lattimer JM and Haub MD: Effects of dietary fiber and its components on metabolic health. Nutrients. 2:1266–1289. 2010. View Article : Google Scholar : PubMed/NCBI

22 

Lightowler HJ and Henry CJ: Glycemic response of mashed potato containing high-viscocity hydroxypropylmethylcellulose. Nutr Res. 29:551–557. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Maki KC, Davidson MH, Witchger MS, Dicklin MR and Subbaiah PV: Effects of high-fiber oat and wheat cereals on postprandial glucose and lipid responses in healthy men. Int J Vitam Nutr Res. 77:347–356. 2007. View Article : Google Scholar : PubMed/NCBI

24 

American Diabetes Association: 5, . Glycemic Targets. Diabetes Care. 39(Suppl 1): S39–S46. 2016.PubMed/NCBI

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APA
Kondo, S., Suzuki, A., Kurokawa, M., & Hasumi, K. (2016). Intake of kale suppresses postprandial increases in plasma glucose: A randomized, double-blind, placebo-controlled, crossover study. Biomedical Reports, 5, 553-558. https://doi.org/10.3892/br.2016.767
MLA
Kondo, S., Suzuki, A., Kurokawa, M., Hasumi, K."Intake of kale suppresses postprandial increases in plasma glucose: A randomized, double-blind, placebo-controlled, crossover study". Biomedical Reports 5.5 (2016): 553-558.
Chicago
Kondo, S., Suzuki, A., Kurokawa, M., Hasumi, K."Intake of kale suppresses postprandial increases in plasma glucose: A randomized, double-blind, placebo-controlled, crossover study". Biomedical Reports 5, no. 5 (2016): 553-558. https://doi.org/10.3892/br.2016.767