Emerging role of microRNA-21 in cancer (Review)

  • Authors:
    • Yin-Hsun Feng
    • Chao-Jung Tsao
  • View Affiliations

  • Published online on: August 26, 2016     https://doi.org/10.3892/br.2016.747
  • Pages: 395-402
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Abstract

MicroRNAs (miRs) are a class of single-stranded RNA molecules of 15-27 nucleotides in length that regulate gene expression at the post-translational level. miR-21 is one of the earliest identified cancer-promoting ‘oncomiRs’, targeting numerous tumor suppressor genes associated with proliferation, apoptosis and invasion. The regulation of miR-21 and its role in carcinogenesis have been extensively investigated. Recent studies have focused on the diagnostic and prognostic value of miR-21 as well as its implication in the drug resistance of human malignancies. The further use of miR-21 as a biomarker and target for cancer treatments is likely to improve the outcome for patients with cancer. The present review highlights recent findings associated with the importance of miR-21 in hematological and non-hematological malignancies.
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October 2016
Volume 5 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Feng, Y., & Feng, Y. (2016). Emerging role of microRNA-21 in cancer (Review). Biomedical Reports, 5, 395-402. https://doi.org/10.3892/br.2016.747
MLA
Feng, Y., Tsao, C."Emerging role of microRNA-21 in cancer (Review)". Biomedical Reports 5.4 (2016): 395-402.
Chicago
Feng, Y., Tsao, C."Emerging role of microRNA-21 in cancer (Review)". Biomedical Reports 5, no. 4 (2016): 395-402. https://doi.org/10.3892/br.2016.747