Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications (Review)

  • Authors:
    • Zhengrong Guo
    • Huanyan Peng
    • Jiwen Kang
    • Dianxing Sun
  • View Affiliations

  • Published online on: March 23, 2016     https://doi.org/10.3892/br.2016.639
  • Pages: 528-534
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Abstract

Cell-penetrating peptides (CPPs), also known as protein transduction domains, are a class of diverse peptides with 5‑30 amino acids. CPPs are divided into cationic, amphipathic and hydrophobic CPPs. They are able to carry small molecules, plasmid DNA, small interfering RNA, proteins, viruses, imaging agents and other various nanoparticles across the cellular membrane, resulting in internalization of the intact cargos. However, the mechanisms of CPP internalization remain to be elucidated. Recently, CPPs have received considerable attention due to their high transduction efficiency and low cytotoxicity. These peptides have a significant potential for diagnostic and therapeutic applications, such as delivery of fluorescent or radioactive compounds for imaging, delivery of peptides and proteins for therapeutic application, and delivery of molecules into induced pluripotent stem cells for directing differentiation. The present study reviews the classifications and transduction mechanisms of CPPs, as well as their potential applications.
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May 2016
Volume 4 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Guo, Z., Peng, H., Kang, J., & Sun, D. (2016). Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications (Review). Biomedical Reports, 4, 528-534. https://doi.org/10.3892/br.2016.639
MLA
Guo, Z., Peng, H., Kang, J., Sun, D."Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications (Review)". Biomedical Reports 4.5 (2016): 528-534.
Chicago
Guo, Z., Peng, H., Kang, J., Sun, D."Cell-penetrating peptides: Possible transduction mechanisms and therapeutic applications (Review)". Biomedical Reports 4, no. 5 (2016): 528-534. https://doi.org/10.3892/br.2016.639