Open Access

Role of oxidative stress in Alzheimer's disease (Review)

  • Authors:
    • Wen‑Juan Huang
    • Xia Zhang
    • Wei‑Wei Chen
  • View Affiliations

  • Published online on: March 15, 2016     https://doi.org/10.3892/br.2016.630
  • Pages: 519-522
  • Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Alzheimer's disease (AD) is the most common cause of disability in individuals aged >65 years worldwide. AD is characterized by the abnormal deposition of amyloid β (Aβ) peptide, and intracellular accumulation of neurofibrillary tangles of hyperphosphorylated τ protein and dementia. The neurotoxic oligomer Aβ peptide, which is the neuropathological diagnostic criterion of the disease, together with τ protein, are mediators of the neurodegeneration that is among the main causative factors. However, these phenomena are mainly initiated and enhanced by oxidative stress, a process referring to an imbalance between antioxidants and oxidants in favour of oxidants. This imbalance can occur as a result of increased free radicals or a decrease in antioxidant defense, free radicals being a species that contains one or more unpaired electrons in its outer shell. The major source of potent free radicals is the reduction of molecular oxygen in water, that initially yields the superoxide radical, which produces hydrogen peroxide by the addition of an electron. The reduction of hydrogen peroxide produces highly reactive hydroxyl radicals, termed reactive oxygen species (ROS) that can react with lipids, proteins, nucleic acids, and other molecules and may also alter their structures and functions. Thus, tissues and organs, particularly the brain, a vulnerable organ, are affected by ROS due to its composition. The brain is largely composed of easily oxidizable lipids while featuring a high oxygen consumption rate. The current review examined the role of oxidative stress in AD.

References

1 

Andreyev AY, Kushnareva YE and Starkov AA: Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc). 70:200–214. 2005. View Article : Google Scholar : PubMed/NCBI

2 

Leeuwenburgh C and Heinecke JW: Oxidative stress and antioxidants in exercise. Curr Med Chem. 8:829–838. 2001. View Article : Google Scholar : PubMed/NCBI

3 

Sheldon RA: Metal-catalyzed oxidations of organic compounds: mechanistic principles and synthetic methodology including biochemical processes. Elsevier. New York, NY: 2012.

4 

Valko M, Rhodes CJ, Moncol J, Izakovic M and Mazur M: Free radicals, metals and antioxidants in oxidative stress-induced cancer. Chem Biol Interact. 160:1–40. 2006. View Article : Google Scholar : PubMed/NCBI

5 

Halliwell B: Reactive oxygen species and the central nervous system. Free radicals in the brain. Springer Berlin Heidelberg. (New York, NY). 21–40. 1992. View Article : Google Scholar

6 

Bambrick L, Kristian T and Fiskum G: Astrocyte mitochondrial mechanisms of ischemic brain injury and neuroprotection. Neurochem Res. 29:601–608. 2004. View Article : Google Scholar : PubMed/NCBI

7 

Lee J, Koo N and Min D: Reactive oxygen species, aging, and antioxidative nutraceuticals. Compr Rev Food Sci Food Saf. 3:21–33. 2004. View Article : Google Scholar

8 

Smith KJ, Kapoor R and Felts PA: Demyelination: The role of reactive oxygen and nitrogen species. Brain Pathol. 9:69–92. 1999. View Article : Google Scholar : PubMed/NCBI

9 

Turrens JF: Mitochondrial formation of reactive oxygen species. J Physiol. 552:335–344. 2003. View Article : Google Scholar : PubMed/NCBI

10 

Dalle-Donne I, Rossi R, Giustarini D, Milzani A and Colombo R: Protein carbonyl groups as biomarkers of oxidative stress. Clin Chim Acta. 329:23–38. 2003. View Article : Google Scholar : PubMed/NCBI

11 

Clarke JR, Lyra E, Silva NM, Figueiredo CP, Frozza RL, Ledo JH, Beckman D, Katashima CK, Razolli D, Carvalho BM, Frazão R, et al: Alzheimer-associated Aβ oligomers impact the central nervous system to induce peripheral metabolic deregulation. EMBO Mol Med. 7:190–210. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Beal MF: Mitochondrial dysfunction in neurodegenerative diseases. Biochim Biophys Acta. 1366:211–223. 1998. View Article : Google Scholar : PubMed/NCBI

13 

Kumar A, Singh A and Ekavali: A review on Alzheimer's disease pathophysiology and its management: An update. Pharmacol Rep. 67:195–203. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Harkany T, Penke B and Luiten PG: β-Amyloid excitotoxicity in rat magnocellular nucleus basalis. Effect of cortical deafferentation on cerebral blood flow regulation and implications for Alzheimer's disease. Ann N Y Acad Sci. 903:374–386. 2000. View Article : Google Scholar : PubMed/NCBI

15 

Walsh DM and Selkoe DJ: Aβ oligomers - a decade of discovery. J Neurochem. 101:1172–1184. 2007. View Article : Google Scholar : PubMed/NCBI

16 

Gelain DP, Antonio Behr G, de Oliveira Birnfeld R and Trujillo M: Antioxidant therapies for neurodegenerative diseases: mechanisms, current trends, and perspectives. Oxid Med Cell Longev. 2012:8951532012. View Article : Google Scholar : PubMed/NCBI

17 

Varadarajan S, Yatin S, Aksenova M and Butterfield DA: Review: Alzheimer's amyloid β-peptide-associated free radical oxidative stress and neurotoxicity. J Struct Biol. 130:184–208. 2000. View Article : Google Scholar : PubMed/NCBI

18 

Parker WD Jr and Davis RE: Primary mitochondrial DNA defects as a causative event in Alzheimer's disease. Mitochondria and free radicals in neurodegenerative diseases. Beal MF, Howell N and Bodis-Wollner I: Wiley-Liss. (New York, NY). 319–333. 1997.

19 

Liochev SI and Fridovich I: Superoxide and iron: Partners in crime. IUBMB Life. 48:157–161. 1999. View Article : Google Scholar : PubMed/NCBI

20 

Hebelstrup KH and Møller IM: Mitochondrial signaling in plants under hypoxia: Use of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Reactive oxygen and nitrogen species signaling and communication in plants. Gupta KJ and Igamberdiev AU: 23:Springer International Publishing. (Switzerland). 63–77. 2015.

21 

Zhang X and Gao F: Imaging mitochondrial reactive oxygen species with fluorescent probes: Current applications and challenges. Free Radic Res. 49:374–382. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Reeg S and Grune T: Protein oxidation in toxicology. Studies on experimental toxicology and pharmacology. Springer International Publishing. (Switzerland). 81–102. 2015. View Article : Google Scholar

23 

Dröge W: Free radicals in the physiological control of cell function. Physiol Rev. 82:47–95. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Panieri E and Santoro MM: ROS signaling and redox biology in endothelial cells. Cell Mol Life Sci. 72:3281–3303. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Rubbo H, Radi R, Trujillo M, Telleri R, Kalyanaraman B, Barnes S, Kirk M and Freeman BA: Nitric oxide regulation of superoxide and peroxynitrite-dependent lipid peroxidation. Formation of novel nitrogen-containing oxidized lipid derivatives. J Biol Chem. 269:26066–26075. 1994.PubMed/NCBI

26 

Stadtman ER and Levine RL: Protein oxidation. Ann N Y Acad Sci. 899:191–208. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Kaur H and Halliwell B: Evidence for nitric oxide-mediated oxidative damage in chronic inflammation. Nitrotyrosine in serum and synovial fluid from rheumatoid patients. FEBS Lett. 350:9–12. 1994. View Article : Google Scholar : PubMed/NCBI

28 

Cheeseman KH and Slater TF: An introduction to free radical biochemistry. Br Med Bull. 49:481–493. 1993.PubMed/NCBI

29 

Mustafa SA, Karieb SS, Davies SJ and Jha AN: Assessment of oxidative damage to DNA, transcriptional expression of key genes, lipid peroxidation and histopathological changes in carp Cyprinus carpio L. following exposure to chronic hypoxic and subsequent recovery in normoxic conditions. Mutagenesis. 30:107–116. 2015. View Article : Google Scholar : PubMed/NCBI

30 

Therade-Matharan S, Laemmel E, Duranteau J and Vicaut E: Reoxygenation after hypoxia and glucose depletion causes reactive oxygen species production by mitochondria in HUVEC. Am J Physiol Regul Integr Comp Physiol. 287:R1037–R1043. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Hwang HJ, Lynn SG, Vengellur A, Saini Y, Grier EA, Ferguson-Miller SM and LaPres JJ: Hypoxia inducible factors modulate mitochondrial oxygen consumption and transcriptional regulation of nuclear-encoded electron transport chain genes. Biochemistry. 54:3739–3748. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Babior BM: Phagocytes and oxidative stress. Am J Med. 109:33–44. 2000. View Article : Google Scholar : PubMed/NCBI

33 

Babior BM: The NADPH oxidase of endothelial cells. IUBMB Life. 50:267–269. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Vignais PV: The superoxide-generating NADPH oxidase: Structural aspects and activation mechanism. Cell Mol Life Sci. 59:1428–1459. 2002. View Article : Google Scholar : PubMed/NCBI

35 

Coon MJ, Ding XX, Pernecky SJ and Vaz AD: Cytochrome P450: Progress and predictions. FASEB J. 6:669–673. 1992.PubMed/NCBI

36 

Hlavica P: Mechanistic basis of electron transfer to cytochromes P450 by natural redox partners and artificial donor constructs. Monooxygenase, peroxidase and peroxygenase properties and mechanisms of cytochrome P450. Hrycay EG and Bandiera SM: 851:Springer International Publishing. (Switzerland). 247–297. 2015. View Article : Google Scholar

37 

Yokoyama Y, Beckman JS, Beckman TK, Wheat JK, Cash TG, Freeman BA and Parks DA: Circulating xanthine oxidase: Potential mediator of ischemic injury. Am J Physiol. 258:G564–G570. 1990.PubMed/NCBI

38 

Kehrer JP: Free radicals as mediators of tissue injury and disease. Crit Rev Toxicol. 23:21–48. 1993. View Article : Google Scholar : PubMed/NCBI

39 

Corvo ML, Marinho HS, Marcelino P, Lopes RM, Vale CA, Marques CR, Martins LC, Laverman P, Storm G and Martins MBA: Superoxide dismutase enzymosomes: Carrier capacity optimization, in vivo behaviour and therapeutic activity. Pharm Res. 32:91–102. 2015. View Article : Google Scholar : PubMed/NCBI

40 

Fridovich I: Superoxide radical and superoxide dismutases. Annu Rev Biochem. 64:97–112. 1995. View Article : Google Scholar : PubMed/NCBI

41 

Okado-Matsumoto A and Fridovich I: Subcellular distribution of superoxide dismutases (SOD) in rat liver: Cu, Zn-SOD in mitochondria. J Biol Chem. 276:38388–38393. 2001. View Article : Google Scholar : PubMed/NCBI

42 

Butler J, Koppenol WH and Margoliash E: Kinetics and mechanism of the reduction of ferricytochrome c by the superoxide anion. J Biol Chem. 257:10747–10750. 1982.PubMed/NCBI

43 

Marí M, Morales A, Colell A, García-Ruiz C and Fernandez-Checa JC: Oxidative stress in nonalcoholic fatty liver disease. Studies on hepatic disorders. Albano E and Parola M: Springer International Publishing. (Switzerland). 279–308. 2015.

44 

Wang T, Lu W, Lu S and Kong J: Protective role of glutathione against oxidative stress in Streptococcus thermophilus. Int Dairy J. 45:41–47. 2015. View Article : Google Scholar

45 

Finkel T and Holbrook NJ: Oxidants, oxidative stress and the biology of ageing. Nature. 408:239–247. 2000. View Article : Google Scholar : PubMed/NCBI

46 

Aboul-Fotouh S: Coenzyme Q10 displays antidepressant-like activity with reduction of hippocampal oxidative/nitrosative DNA damage in chronically stressed rats. Pharmacol Biochem Behav. 104:105–112. 2013. View Article : Google Scholar : PubMed/NCBI

47 

Hoeberichts FA and Woltering EJ: Multiple mediators of plant programmed cell death: Interplay of conserved cell death mechanisms and plant-specific regulators. BioEssays. 25:47–57. 2003. View Article : Google Scholar : PubMed/NCBI

48 

Christen Y: Oxidative stress and Alzheimer disease. Am J Clin Nutr. 71:621S–629S. 2000.PubMed/NCBI

49 

Kozlowski H, Janicka-Klos A, Brasun J, Gaggelli E, Valensin D and Valensin G: Copper, iron, and zinc ions homeostasis and their role in neurodegenerative disorders (metal uptake, transport, distribution and regulation). Coord Chem Rev. 253:2665–2685. 2009. View Article : Google Scholar

50 

Barnham KJ, McKinstry WJ, Multhaup G, Galatis D, Morton CJ, Curtain CC, Williamson NA, White AR, Hinds MG, Norton RS, et al: Structure of the Alzheimer's disease amyloid precursor protein copper binding domain. A regulator of neuronal copper homeostasis. J Biol Chem. 278:17401–17407. 2003. View Article : Google Scholar : PubMed/NCBI

51 

Miura T, Suzuki K, Kohata N and Takeuchi H: Metal binding modes of Alzheimer's amyloid β-peptide in insoluble aggregates and soluble complexes. Biochemistry. 39:7024–7031. 2000. View Article : Google Scholar : PubMed/NCBI

52 

Valko M, Morris H and Cronin MT: ValkoM: Metals, toxicity and oxidative stress. Curr Med Chem. 12:1161–1208. 2005. View Article : Google Scholar : PubMed/NCBI

53 

Strozyk D, Launer LJ, Adlard PA, Cherny RA, Tsatsanis A, Volitakis I, Blennow K, Petrovitch H, White LR and Bush AI: Zinc and copper modulate Alzheimer Abeta levels in human cerebrospinal fluid. Neurobiol Aging. 30:1069–1077. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Butterfield DA: Amyloid β-peptide (1–42)-induced oxidative stress and neurotoxicity: Implications for neurodegeneration in Alzheimer's disease brain. A review. Free Radic Res. 36:1307–1313. 2002. View Article : Google Scholar : PubMed/NCBI

55 

Huang X, Moir RD, Tanzi RE, Bush AI and Rogers JT: Redox-active metals, oxidative stress, and Alzheimer's disease pathology. Ann N Y Acad Sci. 1012:153–163. 2004. View Article : Google Scholar : PubMed/NCBI

56 

Cuajungco MP and Fagét KY: Zinc takes the center stage: Its paradoxical role in Alzheimer's disease. Brain Res Brain Res Rev. 41:44–56. 2003. View Article : Google Scholar : PubMed/NCBI

57 

Pal A, Badyal RK, Vasishta RK, Attri SV, Thapa BR and Prasad R: Biochemical, histological, and memory impairment effects of chronic copper toxicity: A model for non-Wilsonian brain copper toxicosis in Wistar rat. Biol Trace Elem Res. 153:257–268. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Tsaluchidu S, Cocchi M, Tonello L and Puri BK: Fatty acids and oxidative stress in psychiatric disorders. BMC Psychiatry. 8(Suppl 1): S52008. View Article : Google Scholar : PubMed/NCBI

59 

Markesbery WR: Oxidative stress hypothesis in Alzheimer's disease. Free Radic Biol Med. 23:134–147. 1997. View Article : Google Scholar : PubMed/NCBI

60 

Butterfield DA, Hensley K, Cole P, Subramaniam R, Aksenov M, Aksenova M, Bummer PM, Haley BE and Carney JM: Oxidatively induced structural alteration of glutamine synthetase assessed by analysis of spin label incorporation kinetics: Relevance to Alzheimer's disease. J Neurochem. 68:2451–2457. 1997. View Article : Google Scholar : PubMed/NCBI

61 

Moreira PI, Honda K, Liu Q, Aliev G, Oliveira CR, Santos MS, Zhu X, Smith MA and Perry G: Alzheimer's disease and oxidative stress: The old problem remains unsolved. Curr Med Chem Cent Nerv Syst Agents. 5:51–62. 2005. View Article : Google Scholar

62 

Koo EH, Lansbury PT Jr and Kelly JW: Amyloid diseases: Abnormal protein aggregation in neurodegeneration. Proc Natl Acad Sci USA. 96:9989–9990. 1999. View Article : Google Scholar : PubMed/NCBI

63 

Markesbery WR: The role of oxidative stress in Alzheimer disease. Arch Neurol. 56:1449–1452. 1999. View Article : Google Scholar : PubMed/NCBI

64 

Dawnay AB and Millar DJ: Glycation and advanced glycation end-product formation with icodextrin and dextrose. Perit Dial Int. 17:52–58. 1997.PubMed/NCBI

65 

Cooke MS, Evans MD, Dizdaroglu M and Lunec J: Oxidative DNA damage: Mechanisms, mutation, and disease. FASEB J. 17:1195–1214. 2003. View Article : Google Scholar : PubMed/NCBI

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APA
Huang, W., Zhang, X., & Chen, W. (2016). Role of oxidative stress in Alzheimer's disease (Review). Biomedical Reports, 4, 519-522. https://doi.org/10.3892/br.2016.630
MLA
Huang, W., Zhang, X., Chen, W."Role of oxidative stress in Alzheimer's disease (Review)". Biomedical Reports 4.5 (2016): 519-522.
Chicago
Huang, W., Zhang, X., Chen, W."Role of oxidative stress in Alzheimer's disease (Review)". Biomedical Reports 4, no. 5 (2016): 519-522. https://doi.org/10.3892/br.2016.630