Occupational exposure and risk of breast cancer (Review)

  • Authors:
    • Concettina Fenga
  • View Affiliations

  • Published online on: January 21, 2016     https://doi.org/10.3892/br.2016.575
  • Pages: 282-292
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Abstract

Breast cancer is a multifactorial disease and the most commonly diagnosed cancer in women. Traditional risk factors for breast cancer include reproductive status, genetic mutations, family history and lifestyle. However, increasing evidence has identified an association between breast cancer and occupational factors, including environmental stimuli. Epidemiological and experimental studies demonstrated that ionizing and non‑ionizing radiation exposure, night‑shift work, pesticides, polycyclic aromatic hydrocarbons and metals are defined environmental factors for breast cancer, particularly at young ages. However, the mechanisms by which occupational factors can promote breast cancer initiation and progression remains to be elucidated. Furthermore, the evaluation of occupational factors for breast cancer, particularly in the workplace, also remains to be explained. The present review summarizes the occupational risk factors and the associated mechanisms involved in breast cancer development, in order to highlight new environmental exposures that could be correlated to breast cancer and to provide new insights for breast cancer prevention in the occupational settings. Furthermore, this review suggests that there is a requirement to include, through multidisciplinary approaches, different occupational exposure risks among those associated with breast cancer development. Finally, the design of new epigenetic biomarkers may be useful to identify the workers that are more susceptible to develop breast cancer.
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March 2016
Volume 4 Issue 3

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Fenga, C. (2016). Occupational exposure and risk of breast cancer (Review). Biomedical Reports, 4, 282-292. https://doi.org/10.3892/br.2016.575
MLA
Fenga, C."Occupational exposure and risk of breast cancer (Review)". Biomedical Reports 4.3 (2016): 282-292.
Chicago
Fenga, C."Occupational exposure and risk of breast cancer (Review)". Biomedical Reports 4, no. 3 (2016): 282-292. https://doi.org/10.3892/br.2016.575