Pim-1 kinase as cancer drug target: An update (Review)

  • Authors:
    • Yernar Tursynbay
    • Jinfu Zhang
    • Zhi Li
    • Tursonjan Tokay
    • Zhaxybay Zhumadilov
    • Denglong Wu
    • Yingqiu Xie
  • View Affiliations

  • Published online on: December 24, 2015     https://doi.org/10.3892/br.2015.561
  • Pages: 140-146
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

Proviral integration site for Moloney murine leukemia virus-1 (Pim-1) is a serine/threonine kinase that regulates multiple cellular functions such as cell cycle, cell survival, drug resistance. Aberrant elevation of Pim‑1 kinase is associated with numerous types of cancer. Two distinct isoforms of Pim‑1 (Pim‑1S and Pim‑1L) show distinct cellular functions. Pim‑1S predominately localizes to the nucleus and Pim‑1L localizes to plasma membrane for drug resistance. Recent studies show that mitochondrial Pim‑1 maintains mitochondrial integrity. Pim‑1 is emerging as a cancer drug target, particularly in prostate cancer. Recently the potent new functions of Pim‑1 in immunotherapy, senescence bypass, metastasis and epigenetic dynamics have been found. The aim of the present updated review is to provide brief information regarding networks of Pim‑1 kinase and focus on its recent advances as a novel drug target.
View Figures
View References

Related Articles

Journal Cover

February 2016
Volume 4 Issue 2

Print ISSN: 2049-9434
Online ISSN:2049-9442

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
APA
Tursynbay, Y., Zhang, J., Li, Z., Tokay, T., Zhumadilov, Z., Wu, D., & Xie, Y. (2016). Pim-1 kinase as cancer drug target: An update (Review). Biomedical Reports, 4, 140-146. https://doi.org/10.3892/br.2015.561
MLA
Tursynbay, Y., Zhang, J., Li, Z., Tokay, T., Zhumadilov, Z., Wu, D., Xie, Y."Pim-1 kinase as cancer drug target: An update (Review)". Biomedical Reports 4.2 (2016): 140-146.
Chicago
Tursynbay, Y., Zhang, J., Li, Z., Tokay, T., Zhumadilov, Z., Wu, D., Xie, Y."Pim-1 kinase as cancer drug target: An update (Review)". Biomedical Reports 4, no. 2 (2016): 140-146. https://doi.org/10.3892/br.2015.561