Study of the in vitro cytotoxicity testing of medical devices (Review)

  • Authors:
    • Weijia Li
    • Jing Zhou
    • Yuyin Xu
  • View Affiliations

  • Published online on: June 19, 2015     https://doi.org/10.3892/br.2015.481
  • Pages: 617-620
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Abstract

The cytotoxicity test is one of the biological evaluation and screening tests that use tissue cells in vitro to observe the cell growth, reproduction and morphological effects by medical devices. Cytotoxicity is preferred as a pilot project test and an important indicator for toxicity evaluation of medical devices as it is simple, fast, has a high sensitivity and can save animals from toxicity. Three types of cytotoxicity test are stated in the International Organization for Standardization 109993‑5: Extract, direct contact and indirect contact tests. The xCELLigence real‑time cell analysis system shows a significant potential in regards to cytotoxicity in recent years. The present review provides a brief insight into the in vitro cytotoxicity testing of medical devices.

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APA
Li, W., Zhou, J., & Xu, Y. (2015). Study of the in vitro cytotoxicity testing of medical devices (Review). Biomedical Reports, 3, 617-620. https://doi.org/10.3892/br.2015.481
MLA
Li, W., Zhou, J., Xu, Y."Study of the in vitro cytotoxicity testing of medical devices (Review)". Biomedical Reports 3.5 (2015): 617-620.
Chicago
Li, W., Zhou, J., Xu, Y."Study of the in vitro cytotoxicity testing of medical devices (Review)". Biomedical Reports 3, no. 5 (2015): 617-620. https://doi.org/10.3892/br.2015.481