Neuroprotection of microRNA in neurological disorders (Review)

  • Authors:
    • Chunmei Wang
    • Bingyuan Ji
    • Baohua Cheng
    • Jing Chen
    • Bo Bai
  • View Affiliations

  • Published online on: June 16, 2014     https://doi.org/10.3892/br.2014.297
  • Pages: 611-619
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Abstract

MicroRNAs (miRNAs) are small, endogenous, non‑coding RNA molecules that function as post‑transcriptional regulators of gene expression by imperfect base‑pairing with the 3'‑untranslated regions of their target mRNAs. Altered expression of numerous miRNAs has been shown to be extensively involved in the pathogenesis of various diseases and cancers. Additionally, the specific expression of miRNAs in the nervous system has indicated that miRNAs are critical for the occurrence and development of neurological diseases. Increasing evidence has shown that specific miRNAs target the expression of particular proteins that are significant in the disease pathogenesis. Therefore, miRNA‑mediated regulation may be important in the occurrence and development of neurological diseases and may function as a novel biomarker and tool for clinical therapy. In the present study, the significance of miRNAs is reviewed in a number of neurological disorders and the possibility of their use in therapeutic interventions is evaluated.
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September 2014
Volume 2 Issue 5

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Wang, C., Ji, B., Cheng, B., Chen, J., & Bai, B. (2014). Neuroprotection of microRNA in neurological disorders (Review). Biomedical Reports, 2, 611-619. https://doi.org/10.3892/br.2014.297
MLA
Wang, C., Ji, B., Cheng, B., Chen, J., Bai, B."Neuroprotection of microRNA in neurological disorders (Review)". Biomedical Reports 2.5 (2014): 611-619.
Chicago
Wang, C., Ji, B., Cheng, B., Chen, J., Bai, B."Neuroprotection of microRNA in neurological disorders (Review)". Biomedical Reports 2, no. 5 (2014): 611-619. https://doi.org/10.3892/br.2014.297