DNA methylation as an early diagnostic marker of cancer (Review)

  • Authors:
    • Yuanyuan Dong
    • Haiyang Zhao
    • Haiyan Li
    • Xiaokun Li
    • Shulin Yang
  • View Affiliations

  • Published online on: February 14, 2014     https://doi.org/10.3892/br.2014.237
  • Pages: 326-330
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Abstract

DNA methylation is one of the essential epigenetic mechanisms that are closely correlated with the mechanisms underlying cell growth, differentiation and transformation in eukaryotes. global changes in the epigenetic landscape are considered to be a hallmark of cancer. The initiation and progression of cancer are mediated through epigenetic modifications along with genetic alterations. Aberrant methylation of promoter regions is an epigenetic abnormality of the human genome that is highly characteristic of cancer. In this review, we aimed to summarize our current understanding of the alterations in the epigenetic landscape and investigate the potential use of DNA and RNA methylation in effective molecular treatment strategies.

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May 2014
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APA
Dong, Y., Zhao, H., Li, H., Li, X., & Yang, S. (2014). DNA methylation as an early diagnostic marker of cancer (Review). Biomedical Reports, 2, 326-330. https://doi.org/10.3892/br.2014.237
MLA
Dong, Y., Zhao, H., Li, H., Li, X., Yang, S."DNA methylation as an early diagnostic marker of cancer (Review)". Biomedical Reports 2.3 (2014): 326-330.
Chicago
Dong, Y., Zhao, H., Li, H., Li, X., Yang, S."DNA methylation as an early diagnostic marker of cancer (Review)". Biomedical Reports 2, no. 3 (2014): 326-330. https://doi.org/10.3892/br.2014.237