Drug‑loaded nano‑microcapsules delivery system mediated by ultrasound‑targeted microbubble destruction: A promising therapy method (Review)

  • Authors:
    • Jing Ma
    • Lian Fang Du
    • Ming Chen
    • Hang Hui Wang
    • Ling Xi Xing
    • Li Fang Jing
    • Yun Hua Li
  • View Affiliations

  • Published online on: May 21, 2013     https://doi.org/10.3892/br.2013.110
  • Pages: 506-510
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Abstract

The nano‑microcapsules drug delivery system is currently a promising method for the treatment of many types of diseases, particularly tumors. However, the drug delivery efficiency does not reach a satisfactory level to meet treatment demands. Therefore, the effectiveness of delivery needs to be improved. Based on the alterations in the structure and modification of nano‑microcapsules, ultrasound‑targeted microbubble destruction (UTMD), a safe physical targeted method, may increase tissue penetration and cell membrane permeability, aiding the drug‑loaded nano‑microcapsules ingress the interior of targeted tissues and cells. The effectiveness and exact mechanism of action of the drug‑loaded nano‑microcapsules delivery system mediated by UTMD have yet to be fully elucidated. In this study, the latest advancement in UTMD‑mediated drug loaded nano‑microcapsules system technology was reviewed and the hindrances of UTMD‑mediated drug delivery were assessed, in combination with a prospective study. The findings suggested that the drug delivery efficiency of nano‑microcapsules mediated by UTMD was distinctly improved. Thus, the UTMD‑mediated drug‑loaded nano‑microcapsules delivery system may significantly improve the efficiency of drug delivery, which may be a promising new therapeutic method.
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July-August 2013
Volume 1 Issue 4

Print ISSN: 2049-9434
Online ISSN:2049-9442

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APA
Ma, J., Du, L.F., Chen, M., Wang, H.H., Xing, L.X., Jing, L.F., & Li, Y.H. (2013). Drug‑loaded nano‑microcapsules delivery system mediated by ultrasound‑targeted microbubble destruction: A promising therapy method (Review). Biomedical Reports, 1, 506-510. https://doi.org/10.3892/br.2013.110
MLA
Ma, J., Du, L. F., Chen, M., Wang, H. H., Xing, L. X., Jing, L. F., Li, Y. H."Drug‑loaded nano‑microcapsules delivery system mediated by ultrasound‑targeted microbubble destruction: A promising therapy method (Review)". Biomedical Reports 1.4 (2013): 506-510.
Chicago
Ma, J., Du, L. F., Chen, M., Wang, H. H., Xing, L. X., Jing, L. F., Li, Y. H."Drug‑loaded nano‑microcapsules delivery system mediated by ultrasound‑targeted microbubble destruction: A promising therapy method (Review)". Biomedical Reports 1, no. 4 (2013): 506-510. https://doi.org/10.3892/br.2013.110